Hey guys, did anyone warn you that you might get anti-Sperm antibodies from the covid vaccination and become infertile?
"Infertility was often considered a female issue, but male infertility emerged significantly after the Covid-19 pandemic."
Out of 133 samples tested by the university, abnormal sperm indicating infertility made up "percentages between 43.85% and 46.33%".
Mohammed Ahmed Alkireidmi
Now, let's look at a few more studies to understand how Covid-19 and the vaccine effect male reproductive health:
Study 1
"High ACE2 expression was noted in testicular cells, mostly in seminiferous ducts, where the spermatozoa are generated... ACE2 was highly expressed in spermatogonia... if spermatogonia cells were infected and damaged by SARS-CoV-2, spermatogenesis would be disrupted."
The cells in the testicles and sperm have high levels of ACE2 receptors–the receptors that the virus is able to infect. If these cells became infected with the virus, sperm production would be harmed.
"ACE2 plays a significant role in sperm functions. When ACE2 positive cells were infected with SARS-CoV-2, male gamete production was downregulated, but viral reproduction and transmission is greatly enriched in infected ACE2-positive spermatogonia while mitochondria and reproduction-related gene ontology are declined."
When these cells are infected, they become virus producers that can infect other sperm cells–this cell transformation into a virus factory occurs at the expense of cellular mitochondrial and reproductive-related genes.
"Previous studies have confirmed that ACE2 is a cellular receptor for SARS, and evidence of orchitis, testicular damage, germ cell destruction, thick basement membrane, and defective spermatogenesis were reported in patients infected with the disease. SARS-CoV-2 and SARS share considerable genetic identities and use the same receptor for entry into host cells. However, they differ in the reproductive propagation, SARS-CoV-2 being higher than in SARS."
The coronavirus SARS was found to cause orchitis, testicular damage, germ cell destruction, thick basement membrane (thickening of the membrane of seminiferous tubules), and defective sperm production. SARS-COV-2 is basically the new and improved version of SARS, sharing 80% identical DNA and infecting the same cell receptors. So we can assume that SARS-COV-2 is capable of all the harm that SARS is capable of. The only difference is SARS-COV-2 has higher reproductive propagation. This means that SARS‑CoV‑2 can infect and multiply more efficiently in testicular cells, leading to even more severe and widespread reproductive damage compared to SARS.
The image in the middle shows healthy seminiferous tubules, the image on the right shows thickened seminiferous tubules due to inflammation.
"Blood-testis barrier (BTB) protects the testicular cells, especially germ cells from cytokine storms. However, the testis is not completely protected from local and systemic inflammation activators and cannot be isolated from the immune system especially when viremia occurs... During the acute phase of SARS-CoV-2, BTB cannot prevent virus infiltration and infection, so the virus is shed into the reproductive tract. Inflammatory cytokines, produced through cytokine storm, are locally or systematically produced by these cells. Thereby, autoimmune response promotes and destroys the seminiferous epithelium and autoimmune orchitis occurs. Subsequently, the viral infection causes deterioration of spermatogenesis, steroidogenesis, and fertility. From the antibody production perspective, SARS-CoV-2 causes severe orchitis by extensive IgG precipitation in testicular tissue, causing testicular leukocyte infiltration and germ cell damage."
Like the blood-brain barrier, the testes have a blood-testis barrier to protect them from disruption. But, like the blood-brain barrier, when there's a severe cytokine storm, systemic inflammation can disrupt the barrier and allow the virus to infect the reproductive cells. When the virus is able to infect cells in the testis, it causes sperm production to decreases and destroys testicular cells ability to use cholesterol to produce hormones needed for healthy function (THIS IS ANOTHER REASON WHY STATINS ARE SO HARMFUL).
Ok, but this is all talking about the viral infection, what does this mean for the mRNA vaccine? Can the mRNA vaccine cause the same damage through similar or parallel means?
Yes, because the vaccine produces an extreme and extremely drawn out cytokine storm with no means of being turned off by the body. This can disrupt the BTB allowing mRNA to enter the testicles, which is arguably more harmful than the virus because it causes the cells to start producing the encoded spike protein.
Wild viruses have co-evolved with their hosts over time. They have mechanisms to dampen local immune responses or avoid provoking a damaging autoimmune reaction in sensitive tissues like the testis. Vaccine mRNA, on the other hand, is synthetic and designed solely to produce antigen to stimulate immunity. If it reaches the testis, there is no “natural” braking mechanism to prevent an overactive immune response, leading to severe inflammation and damage.
Even a small amount of mRNA crossing the BTB could lead to prolonged expression of the viral antigen. This sustained antigen presence could contribute to an autoimmune attack against testicular cells, disrupting the structure of the seminiferous tubules and impairing spermatogenesis.
✉Corresponding author.
Study 2
Published January 31, 2024
So this study was able to confidently conclude that vaccination was not statistically associated with sperm quality parameters except for curvilinear velocity [VCL], average path velocity [VAP], straight-line velocity [VSL].
But these velocity measurements are critical indicators of sperm motility and, by extension, fertility.
Online Submission
Study 3
Consider the phrasing of the findings of the study above: "no significant adverse effects of vaccination was noted".
Well, what constitutes as a significant adverse effect? Who and what determines what is significant?
Because it's not saying there that were no adverse effects. It's not saying they proved with absolute certainty that the vaccines had no adverse effect on sperm health. It's just saying there were adverse effects, but they just didn't find them to be significant.
Discussion